Sean Lee arrived in Dallas as a Second Round Pick from Penn State in 2010 and was their starting Middle Linebacker as a sophomore. Lee would lead the NFL in Interception Return Yards (174) in 2013, but a torn ACL took him out of the entire 2014 Season.
Despite the setback, Lee returned to the Cowboys, and put forth the best back-to-back campaigns of his professional career. Lee went to the Pro Bowl with a 128-Tackle year, and in 2016, he improved it to 145 with an Approximate Value of 19. He was so impressive, that he was chosen to be a First Team All-Pro.
Lee played four more seasons, but injury after injury compounded, and he retired after the 2020 Season.
From American Samoa, Mike Iupati was an All-American at Idaho, and it propelled him to a First Round Selection by the San Francisco 49ers in 2010. Not surprisingly, he won the starting Left Guard job with the Niners, and he had his breakout year in 2012, earning First Team All-Pro honors and helping San Francisco reach the Super Bowl. Iupati was a Pro Bowl Selection that year, and would be the next three years, though the last of that streak was as an Arizona Cardinal.
Iupati played for Arizona until 2018, and he finished his career with two years in Seattle.
Along with his twin brother Mike, Maurkice Pouncey was a star Offensive Lineman, who helped the Florida Gators win the National Championship in 2009. Pouncey, who was an All-American, would be taken 18th Overall in 2010 with the Pittsburgh Steelers, and he was their Center for 11 years.
Pouncey proved to be one of the top Centers of the 2010s, winning All-Decade honors with three First Team All-Pros. Protecting Ben Roethlisberger and opening holes for Steelers runners, Pouncey was also chosen for nine Pro Bowls.
Pouncey retired after the 2020 season, alongside his brother, though it his Maurkice who clearly has the far better Hall of Fame chance of the two.
Matt Schaub was the 2002 ACC Player of the Year and it helped put the Virginia Quarterback on the map for the 2004 Draft where he was chosen by the Atlanta Falcons in the Third Round where be backed up Michael Vick for three years. Schaub saw little action as a Falcon, but the belied was that he was ready to be a starter. The Houston Texans agreed with that assessment, and they pulled the trigger and traded for him in 2007.
Schaub took over for the departed David Carr, and after a slow start, he had the best year of his career in 2009 where he led the NFL in Pass Completions (396), Passing Yards (4,770), and he had a career-best 29 Touchdowns. Schaub was a Pro Bowler that year, and he had another 4,000-Yard year in 2010. After missing six Games in 2011, Schaub had one last good year in him with his second Pro Bowl campaign and his last 4,000-Yard campaign.
Schaub was mostly a backup after that, with one more year in Houston, one in Oakland, one in Baltimore and four final seasons back in Atlanta.