A 2^nd Round Pick from Bethune-Cookman, Rashean Mathis became a starting Cornerback as a rookie in 2003.  Mathis had a tumultuous rookie season, but he moved permanently to Left Cornerback, and over the next few years, he was in that second tier of DBs in the NFL. 

Keenan McCardell played his first four years in the NFL with the Cleveland Browns, and he saw a lot more playing time in his final season there (1995), where he had 56 Receptions.  McCardell would sign with the Jaguars in 1996, and he would play there for six seasons and would have the best run of his career.

Playing his entire career with the Jacksonville Jaguars, Brad Meester was a 2^nd Round Pick from Northern Iowa who would secure a long career in Pro Football.

Maurice Jones-Drew was a second round pick from UCLA in 2006, and in his first three seasons in Pro Football, he did well.  While he never had a year in that time period where he reached 1,000 Rushing Yards, he had 34 Rushing Touchdowns, which was a good number in any three-year stretch.