Playing his college ball at San Diego State, Gary Garrison was one of the many players in the 1960s who was drafted in both the National Football League and American Football League.  Garrison stayed in San Diego, joining the Chargers, who drafted him instead of Philadelphia of the NFL.

After playing his rookie season with the Houston Oilers, Doug Wilkerson was traded to the San Diego Chargers for Tight End, Willie Frazier.  Frazier had been a two-time AFL All-Star for the Chargers, but his best days were behind him.  Wilkerson went on to play 14 years for San Diego.

Leslie O'Neal had a phenomenal (or tragic) rookie season for the San Diego Chargers, who took the Oklahoma State Cowboy with their First Round Pick.  Not only was O'Neal an All-Rookie, but he was also named the Defensive Rookie of the Year.  However, it was equally tragic as he injured his knee, which ended not only that year, but the following season and half of the next one.

A former Defensive Player of the Year at Mizzou, Russ Washington parlayed that into the Fourth Overall Pick of the 1968 Draft.