Niedermayer signed with Anaheim in August of 2005 as a Free Agent and was the runner-up for the Norris and a First Team All-Star in his first year as a Duck. The year after, the Mighty Ducks of Anaheim became the Anaheim Ducks, and the transformation also coincided with the Ducks' first Stanley Cup win. That year, Niedermayer was the Conn Smythe winner and was again a First Team All-Star.
The blueliner played three more years with the Ducks and was a two-time All-Star with the team. Niedermayer played until the 2010 season and had 264 Points in 371 Games.
Niedermayer entered the Hockey Hall of Fame in 2013, his first year of eligibility.