Keith Lincoln came out of Washington State and chose the Chargers over the Buffalo Bills, who had also drafted him in 1961, signing with San Diego as a second-round AFL pick. He saw limited action as a rookie, then became a regular the following year and earned AFL All-Star honors for the next four seasons. He was a tough, versatile back who could run between the tackles, catch passes out of the backfield, and even throw the occasional option pass, giving Sid Gillman’s offense another weapon who could move the chains or break a big play.

His peak arrived in 1963, when he rushed for 826 yards and earned First-Team All-AFL honors. That year the Chargers won the AFL championship, and Lincoln was named the game’s MVP after a dominant performance against the Boston Patriots. He carried 13 times for 206 yards (including a 67-yard touchdown), caught seven passes for 123 yards and a score, and even completed a 20-yard pass, finishing with a then-record 329 yards from scrimmage in the 51-10 rout. He repeated as a First-Team All-AFL selection in 1964 and remained a productive dual-threat through the mid-1960s, mixing power runs with receiving production that kept defenses from focusing solely on halfback Paul Lowe or the serious threats outside.

Lincoln stayed with the Chargers until he joined the Bills in 1967. Across his primary stretch in San Diego, he accumulated roughly 7,000 all-purpose yards, making him one of the more complete offensive contributors of the early Chargers era.In 1980, the franchise enshrined him in its Hall of Fame, recognizing the multi-purpose back whose championship-game performance remains one of the most memorable individual efforts in the franchise’s history.

Melvin Ingram arrived in San Diego as a first-round pick out of South Carolina in 2012 and spent his rookie season mostly as a backup linebacker and special-teams contributor. A torn ACL in his second training camp wiped out nearly all of 2013, but he returned late that year and helped the Chargers reach the playoffs for the first time since 2009. From there, he steadily worked his way into a starting role on the edge. He was a versatile, athletic rusher who could line up as a stand-up linebacker or with his hand in the dirt, using speed, spin moves, and quick hands to get around tackles or work inside on stunts.

His breakout came in 2015, when he posted 10.5 sacks, 19 tackles for loss, and four forced fumbles while starting every game. He matched that sack total in 2017, earned AFC Defensive Player of the Month honors for September, and made his first Pro Bowl. That started a three-year run of Pro Bowl selections from 2017 through 2019, during which he formed a productive edge tandem with Joey Bosa. He finished 2017 with another 10.5 sacks and added a 39-yard scoop-and-score touchdown, and he remained a consistent pressure generator through 2018 and 2019 even as the Chargers’ defensive line evolved. He was the kind of player who could win with pure speed off the edge one snap, then counter with a spin or bull rush the next, forcing quarterbacks to hurry throws and creating opportunities for the rest of the front. After the 2020 season, Ingram left for the Pittsburgh Steelers. 

In his nine years with the Chargers, he finished just shy of 50 sacks and ranked among the franchise's more productive edge defenders during that stretch.

He never quite reached the same individual heights after leaving San Diego, but his multi-year stretch of Pro Bowls and double-digit sack seasons with the Chargers marked him as one of the more reliable pass rushers the team has had in the modern era.

Kenny Graham became a Charger after the 1963 college season when San Diego selected the Washington State safety in the 13th round of the AFL draft. The Baltimore Colts also selected him in the NFL Draft, but in May 1964 he signed with the Chargers, joining the team the year after it won its only AFL championship. The late-round pick out of the Cougars quickly stepped into a starting role at safety and began producing turnovers right away.

At about 6-foot and 210 pounds, he was a rangy, physical safety who could cover deep and still come up and deliver hits against the run. In his first season, he picked off four passes, then followed with five interceptions in three of the next four years. He was an AFL All-Star four times (1965, 1967, 1968, and 1969) and earned First-Team All-AFL honors in 1966—ironically one of the two years he did not make the All-Star team. He returned five of his interceptions for touchdowns during his Chargers run, including a 68-yarder in 1967 and a pair of scores in 1969. He was the kind of safety who could erase a deep throw one play, then turn a short interception into a big return the next, giving San Diego a reliable playmaker in the back end throughout the mid-to-late 1960s.

After the 1969 season, Graham left for the Cincinnati Bengals, where he played one final year before wrapping up his career. Across his six seasons with the Chargers, he finished with 25 interceptions and five return touchdowns, production that still ranks among the better totals for a safety in franchise history.

He was later named to the AFL All-Time Second Team, recognition for the productive, ball-hawking safety who spent most of the 1960s locking down the back end for San Diego.

“The Big Cat” Ernie Ladd arrived in San Diego as a late-round find from Grambling in 1961, and at 6-foot-9 and around 290–315 pounds, he was one of the largest humans ever to play the game. Historically Black colleges weren’t heavily scouted by pro teams then, so the Chargers got a steal when they brought in the massive defensive tackle. As a rookie, he started every game at right defensive tackle, earned First-Team All-AFL honors, and helped the team reach the AFL Championship Game. He used that rare combination of size, strength, and surprising agility to clog the middle and disrupt both the run and the pass, quickly becoming a cornerstone of the early Chargers defense.

Over the next few seasons, Ladd stayed a consistent force. He was an AFL All-Star four straight years from 1962 to 1965 and earned First-Team All-AFL honors again in 1964 and 1965. In 1962 he led the team with 9.5 unofficial sacks, and in 1963 he was part of the original “Fearsome Foursome” defensive line (alongside Earl Faison and others) that helped the Chargers win the AFL Championship with a 51-10 rout of Boston. Even when injuries limited his starts in 1963, he still contributed on a unit that made four AFL title games in his five seasons. Opponents described him as almost impossible to block cleanly; one center said trying to handle him was like being locked in a closet.

After the 1965 season, Ladd signed with the Houston Oilers. He had already begun wrestling in the offseason, and the Chargers had been told he might eventually leave football for the ring full-time—which he did a couple of years later. Across his five seasons in San Diego, he had been a four-time AFL All-Star, a three-time First-Team All-AFL selection, and a key piece of the 1963 championship team.

In 1981, the Chargers inducted “The Big Cat” into their Hall of Fame, recognizing the imposing defensive tackle who had helped define the franchise’s early defensive identity before trading the gridiron for a long and successful second career in professional wrestling.