Fox won the starting Second Base job for the White Sox in his first season there (1950), and from 1951 to 1961, he was a perennial All-Star, earning another one in 1963, which was his last season in Chicago. Fox would become a certifiable hitting machine. He would lead the American League in Hits four times (1952, 1954, 1957 & 1958), and he would exceed 180 Hits eight times. Fox also batted .300 six times and would bat .291 overall for Chicago. He would win the American League MVP in 1959, the same season that he took the White Sox to win the Pennant. They didn't win the World Series, by Fox batted .375 in the Fall Classic.
Fox was also known for his exemplary defensive skills. He would win three Gold Gloves and would have gained a lot more put the trophy did not come into existence until 1957. Fox led the American League Second Basemen in Total Zone Runs four times and Fielding Percentage six times.Fox would enter the Baseball Hall of Fame in 1997.