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48. Mike Cuellar

Mike Cuellar would become a World Series Champion and a Cy Young winner with the Baltimore Orioles, but he first turned heads when he was a Houston Astro.  Cuellar would go his first All-Star Game as an Astro in 1967, a season where he went 16 and 11.  Overall, in the four seasons he was in Houston (1965-68), he went 37-36 with 557 Strikeouts.

44. Denny Walling

Known for being one of the more prolific Pinch Hitters of all-time, Denny Walling was a Houston Astro for 13 of his 18 seasons and was predominantly used against right handed pitchers.  Walling was especially effective with his bat in the cavernous Astrodome and the fact that he was capable of playing multiple defensive positions made him an asset for Houston.  He would have 726 Hits for the club.

35. Dave Smith

Twice an All-Star as an Astro, Dave Smith was Houston’s closer for years, saving 20 games in six consecutive seasons.   He would record six seasons with a WHIP under 1.100 and would finish on the top five in Saves three times.
In 2015, Dallas Keuchel won the Cy Young Award, cementing himself as a certified ace in Major League Baseball who shot up this list astronomically from that 2015 campaign.  Keuchel did not repeat that season’s accomplishments with the Astros, but he was an All-Star for the second time in 2017, where he had a 14-5 record and a 2.90 ERA.  His run with the Astros ended when he signed with the Atlants Braves as a Free Agent.  With Houston, Keuchel would have a 76-63 record with 945 Strikeouts.