Playing only four games as a rookie due to injury, DeCastro has been relatively healthy since playing at Right Guard, a position he held until the end of the 2020 Season  In 2015, DeCastro was chosen for the Pro Bowl, and the former Louisville Cardinal had a six-year streak earning that accolade.  DeCastro has also been a First Team All-Pro twice.

After being injured for the entirety of the 2021 Season, DeCastro was released by the team and retire after.  History will show DeCastro as one of the better Tackles in Steelers history.