Darren Woodson arrived in Dallas as one of the Draft Picks acquired in the Herschel Walker trade, and the 2^nd Rounder from Arizona State wasted little time establishing himself as a force in the Cowboys Secondary, even though he was a Linebacker in college.  A member of the All-Rookie Team, Woodson aided Dallas to a win in Super Bowl XXVII and subsequently Super Bowl XXVIII and in the season after he would begin a three-year streak of First Team All-Pros and five year run of Pro Bowls.  This period would also see Woodson win his third Super Bowl (XXX). 

In the 1960s, the Los Angeles Rams defense was primarily known for its "Fearsome Foursome" Defensive Line, but there was a star in their Secondary by the name of Eddie Meador, who would be chosen for six Pro Bowls.  Meador came from Arkansas Tech and would become the starting Left Cornerback in his second season.  That year (1960), he would be named to the Pro Bowl, but when he moved to Right Safety in 1964, he was in a better spot for his skill set.  Meador would go to five straight Pro Bowls (1964-68) and was a First Time All-Pro in both 1968 and 1969.

A beast at Temple University, Francis Joseph "Bucko" Kilroy may not have been drafted but his hometown Philadelphia Eagles knew there was something special there and he made the team; albeit in a combined effort as in 1943 the Eagles merged with the Pittsburgh Steelers due to the depletion of talent due to World War II. 

Coming out of the University of Alabama, Shaun Alexander backed up Ricky Watters in his rookie season (2000), and after Watters' retirement, he would become the lead back for the Seattle Seahawks.  Alexander would go on to a five-year run where he exceeded over 1,000 Rushing Yards, but most importantly, would become a touchdown factory.  In 2001, he led the NFL with 14 Rushing TDs and would never go below that in the next four seasons.