While prejudice ran rampant in baseball, Luque gained a pass as a fair-skinned blue-eyed Cuban. After a few games with the Boston Braves (1914 & 1915), he found a home for a dozen years with the Cincinnati Reds. Luque had a phenomenal year in 1923, where he led the National League in Wins (27), ERA (1.93), and FIP (2.94). He would later win a second ERA Title in 1925. From 1919 to 1928, Luque would always have at least 10 Wins.
The Cuban would finish his career with the Brooklyn Robins and New York Giants. He retired in 1935 with a record of 194-179.