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11. Adam Wainwright

The modern history of the St. Louis Cardinals is closely linked to a highly loyal and dominant right-handed pitcher from Georgia. Originally drafted in the first round by the Atlanta Braves, Adam Wainwright was traded to Missouri in December 2003. This trade became one of the most significant and franchise-changing deals in baseball history. Known for his powerful sinker and a legendary 12-to-6 curveball called "Uncle Charlie," Wainwright spent over twenty years becoming a cornerstone of the team. He not only posted impressive stats but also demonstrated relentless competitive spirit and loyalty to the organization. Over time, he transformed from a postseason hero to the standout ace of his era.

After two games with the parent club in 2005, Wainwright became a permanent fixture in 2006, emerging in high-leverage bullpen roles. When veteran closer Jason Isringhausen was injured late in 2006, manager Tony La Russa played the rookie, who responded flawlessly, allowing zero runs over nine postseason appearances. Most famously, he froze Carlos Beltrán with a legendary, physics-defying curveball to capture the National League pennant, before striking out Brandon Inge to secure the 2006 World Series title.

Once he returned to his natural starting role ahead of the 2007 season, Wainwright transformed into a metronomic force at the top of the rotation. His absolute individual peak of regular-season execution erupted during a phenomenal multi-year run surrounding the turn of the decade. He led the National League with a career-high 19 victories in 2009 to claim a close third-place finish in the Cy Young voting.

He truly shined during an incredible 2010 season, earning his first 20-win game with a dazzling 2.42 ERA and 213 strikeouts over 230.1 innings. It was a season that earned him his first career All-Star selection and a close second place in the Cy Young voting behind Roy Halladay.

However, his extensive career must be viewed in light of the serious physical challenges that nearly ended his prime. A torn elbow ligament led to Tommy John surgery, causing him to miss the entire 2011 season—yet he was richly rewarded later with his second World Series ring when his team won the championship that fall.

Proving any doubts about his physical leverage entirely wrong, he engineered a spectacular second act of frontline dominance upon his return.

He dominated the Senior Circuit in 2013 with 19 wins and a league-high 241.2 innings, then obliterated National League lineups in 2014 with 20 wins and a remarkable 2.38 ERA, finishing second and third in consecutive Cy Young races. Wainwright’s legacy was built on exceptional, multi-faceted contributions that set him apart from typical pitchers. He was also a top defender, earning two Gold Glove Awards for his perfect positioning and exceptional internal clock. He was equally dangerous with a bat in his hands, famously launching a home run on the very first pitch he ever saw in the major leagues and capturing a Silver Slugger Award in 2017.

While his final 2023 victory lap was highly suspect due to a severe performance leak—navigating his age-41 season with an ERA near 8.00 and a negative 2.0 bWAR—he displayed incredible baseline resilience to secure his historic, milestone 200th career victory in his final home start against the Milwaukee Brewers.

Across his 18 seasons strictly representing the Cardinals as a true "Lifer," he compiled an even 200–128 record, 2,202 strikeouts, and a stellar 3.38 career ERA over 2,668.1 innings of work.

9. Lou Brock

When a franchise executes a trade that is profoundly imbalanced, altering the entire course of its modern history, the transaction swiftly becomes a quintessential example of executive ill-gotten gains. In June 1964, the St. Louis Cardinals obtained an underperforming and structurally mismanaged outfielder from their longstanding adversaries, the Chicago Cubs, in a notorious multi-player deal centered on pitcher Ernie Broglio. Lou Brock did not merely experience a change of scenery in Missouri; he became an unstoppable force of high-velocity offense. By infusing the roster with a formidable combination of exceptional speed and aggressive contact hitting, the exceptionally swift left fielder embarked on a legendary 16-season tenure that revolutionized the batting order for an entire generation.

His mid-season arrival in 1964 served as an immediate catalyst, resulting in a significant increase in his performance virtually overnight. Brock transformed getting on base into a nightly demonstration, batting an impressive .348 over 103 games during the latter part of the season, thereby contributing to the Redbirds' historic National League pennant victory and ultimately securing the world championship title against the New York Yankees.

Once fully integrated into the local culture, he methodically redefined the art of base running. He achieved his first career stolen base title during an impressive 1966 season, an accomplishment that sparked a remarkable sequence of dominance, whereby he led the National League in stolen bases in eight of nine summers from 1966 through 1974. The pinnacle of his individual base-stealing mastery was exemplified during the exceptional 1974 regular season. At the age of 35, Brock demonstrated an exemplary display of timing and tactical foresight, breaking the modern single-season record by stealing an extraordinary 118 bases and securing a distinguished runner-up position for the National League Most Valuable Player award.

Nevertheless, characterizing Brock exclusively as a baserunning specialist significantly understates the extensive nature of his offensive contributions. He was a distinguished high-volume hitter during his tenure under the Arch, achieving four seasons with 200 hits, in addition to seven seasons in which he exceeded 180 hits.

His big-game DNA was entirely unrivaled when the ultimate prize was on the line. Across three separate World Series appearances (1964, 1967, and 1968), Brock systematically dismantled opposing pitching to forge a mind-bending .391/.424/.655 postseason slash line with 14 doubles, seven triples, four home runs, and a modern Fall Classic-record 14 stolen bases across 21 games.

Where Brock experiences substantial decline under contemporary analytical scrutiny is in his markedly volatile and unidimensional profile. He was widely recognized as a notably aggressive hitter who consistently ranked high on league strikeout leaderboards, recording at least 100 strikeouts in nine separate summers with St. Louis.

Defensively, his metrics were even more problematic; he possessed a highly erratic glove and a limited throwing arm, posting eight separate seasons with a negative defensive bWAR of -1.0 or worse while retiring with the third-most errors recorded by any left fielder in the history of the sport. These massive defensive leaks heavily drag down his advanced efficiency metrics, explaining why his localized value anchors lower in a comprehensive algorithmic review than his traditional status might indicate.

Nevertheless, his historic longevity ultimately earned him inner-circle baseball immortality. During his final 1979 swan song in a Cardinals uniform, the veteran icon joined the sport's most exclusive fraternity, collecting his 3,000th career hit to draw a definitive, storybook curtain on his playing days.

In St. Louis, Brock accumulated 2,713 hits, 434 doubles, 121 triples, and 888 stolen bases, which formed the bulk of his 938 career swiped bags—a historical record that stood until Rickey Henderson eventually redefined the category. He would be inducted into the Baseball Hall of Fame in 1985 on the first ballot, and was also part of the first class inducted into the Cardinals Hall of Fame in 2014.  His number 20 was also retired by the team after he retired in 1979.

13. Johnny Mize

In chronicling the historic, multi-stage career of a baseball player, it is uncommon to encounter a legacy precisely segmented into three definitive acts of excellence. For John Robert Mize, his illustrious journey manifested through three distinct phases: as a structural powerhouse for the St. Louis Cardinals, as a prominent mid-career figure for the New York Giants, and as a distinguished late-career role player who contributed significantly to five consecutive World Series victories with the New York Yankees. However, an exclusive examination of his initial foundational act in eastern Missouri reveals an extraordinary peak of run production that exemplifies exemplary batting mechanics—a legendary apex that nearly diminished before it genuinely commenced.

The entire trajectory nearly shattered during a high-stakes transaction at a pivotal juncture in late 1934. While playing in the minor leagues for Rochester, the young first baseman attracted the interest of the Cincinnati Reds, who agreed to purchase his contract from the Cardinals for an astounding sum of $55,000—an exorbitant amount during the peak of the Great Depression. Nevertheless, Mize sustained a severe, incapacitating injury to his leg and groin, which restricted his mobility. Subsequent medical examinations revealed painful bone spurs, prompting the Reds to annul the agreement and return him to St. Louis. At merely 22 years of age, many commentators believed "The Big Cat" was at the end of his career.

Instead, Cardinals general manager Branch Rickey appointed a specialist to perform surgery, establishing a seminal technical shift. Due to his ongoing recovery, Mize was unable to cope with the routine demands of a minor-league schedule, which resulted in his promotion to the major-league roster in 1936 solely to serve as a part-time pinch hitter. He fundamentally defied expectations by achieving a remarkable .329 batting average over 126 games, thereby securing a regular position in the starting lineup.

By 1937, his iconic, picture-perfect left-handed swing became the most feared weapon in the National League. Mize turned punishing inside fastballs and maintaining supreme plate discipline into a strict daily routine. That summer, he lashed out a .364 batting average with 25 home runs, a .427 on-base percentage, and a commanding .595 slugging mark.

Rather than hitting a ceiling, he systematically unlocked even greater power leverage over the next three seasons, establishing an era of unadulterated dominance. He captured the National League batting title in 1939 with a brilliant .349 average while pacing the Senior Circuit with 28 home runs.

He beautifully backed that up during a magnificent 1940 campaign, hammering a league-high 43 round-trippers and driving in a spectacular 137 runs. His complete dominance is beautifully validated by advanced efficiency metrics; Mize led the National League in slugging percentage and total OPS for three consecutive summers from 1938 to 1940, capturing consecutive MVP runner-up finishes.

The final chapter of his initial run arrived following the 1941 schedule. Eager to transition toward a younger, more flexible roster, ownership executed a sudden business departure, trading their premier first baseman to the New York Giants.

Mize walked away from Sportsman's Park, leaving behind a concentrated statistical fortress that commands profound reverence from modern purists. Across his six seasons strictly representing the Redbirds, he accumulated an astonishing localized slash line of .336/.419/.600, hammering 158 home runs and driving in 531 runs over 854 games.

His immortal contributions were formally immortalized when the Veterans Committee officially punched his first-class ticket to Cooperstown in 1981. Decades later, the organization added the final, beautiful punctuation to his legacy, triumphantly enshrining Johnny Mize as a member of the inaugural St. Louis Cardinals Hall of Fame class in 2014.

10. Joe Medwick

Debuting with the St. Louis Cardinals in 1932, Joe “Ducky” Medwick (thus nicknamed because he apparently walked like that aforementioned bird) would become a major star through the 1930s.  Before he was traded midway through the 1940 season he would have seven full seasons where he batted over .300 with four 200 Hit campaigns.  While in relative terms, Medwick was not known as an elite power hitter he did blast 152 dingers for St. Louis including a league-leading 31 in 1937.  We will get back to that year later.  In addition to decent power, he was a doubles leader three times (1936-38) and had seven straight years with 40 Doubles, and was also a Triples champion in 1934.