Signed as an undrafted free agent out of Colorado in 1997, Matt Lepsis entered the league having played tight end for the Buffaloes. Denver’s legendary offensive line coach Alex Gibbs saw the potential for a swift, agile tackle ideally suited for Gibbs’ zone-blocking scheme, converting Lepsis to the offensive line, where he spent his rookie year learning the ropes and contributing on special teams during Denver's Super Bowl XXXII championship season.

Lepsis earned a full-time starting job in 1999 at right tackle, becoming the key protector on Denver's right side and contributing to the squad's repeat title run in Super Bowl XXXIII. His elite lateral movement made him a force in the run game, helping pave the way for a long line of 1,000-yard rushers, including Olandis Gary, Mike Anderson, Clinton Portis, and Reuben Droughns.

His positional versatility shone through in 2004 when the Broncos asked him to slide over to left tackle to replace long-time anchor Gary Zimmerman's successor, Ephraim Salaam. Lepsis handled the transition seamlessly, locking down the quarterback's blind side for the remainder of his career. Over an extraordinary stretch from 1999 through 2007, he was a steady presence in the trenches, starting 133 out of 134 games he appeared in and only missing significant time due to a torn ACL midway through the 2006 season.

Despite consistently putting together textbook film, Lepsis was repeatedly overlooked for national honors like the Pro Bowl, operating as one of the league's most underrated edge blockers. He retired following the 2007 campaign, walking away on his own terms after a decade spent entirely in Mile High. Lepsis played in 150 regular-season games with 133 starts.