Drafted in the third round (72nd overall) of the 2019 NFL Draft out of North Carolina State, Germaine Pratt arrived in Cincinnati as a former college safety transitioning to full-time off-ball linebacker. Armed with range, explosive downhill trigger speed, and natural coverage instincts, Pratt steadily developed into the physical heartbeat of Lou Anarumo's defense.

Pratt secured a starting position midway through his rookie season, assuming responsibilities as middle linebacker and demonstrating immediate potential against the run. Gradually, he developed his skills into a comprehensive three-down player, becoming a vital component alongside Logan Wilson. He established his place in franchise history during the 2021 postseason by intercepting Derek Carr in the final seconds of the Wild Card round, thereby securing Cincinnati's first playoff victory in 31 years and initiating their journey to Super Bowl LVI.

As the defense cemented its status as a championship contender, Pratt's performance consistently improved. In 2023, he achieved 118 combined tackles and two interceptions, securing a contract extension and establishing himself as one of the most dependable turnover creators at his position. Subsequently, in 2024, he delivered a career-best performance, recording a team-high 143 combined tackles and ranking among the top ten tacklers in the NFL.

Frustrations regarding the organization's direction and roster construction led to a mid-2025 separation, concluding his six-season tenure in Southern Ohio when he was released and briefly joined the Las Vegas Raiders before moving on to Indianapolis. Pratt played in 96 regular-season games (88 starts) and seven playoff contests. He compiled 616 combined tackles, seven interceptions, seven forced fumbles, five fumble recoveries, and 3.5 sacks in the orange stripes.